Special Issue “Functional Proteomics in the Investigation of Protein-Protein Interactions”

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section “Applied Biosciences and Bioengineering“.

Deadline for manuscript submissions: 10 October 2021.

Special Issue Editors

Prof. Dr. Maria Monti

CEINGE-Biotecnologie Avanzate, University of Naples Federico II, Via Gaetano Salvatore, 486 – 80145 Napoli, Italy
Interests: The scientific activity of Prof. Maria Monti has always addressed the structural characterization of proteins and glycoproteins using classical protein chemistry procedures in combination with advanced biomolecular mass spectrometric methodologies, especially studies focused on protein folding, characterization of post-translational modifications, including assignment of S-S bridges, identification of glycosylation and S-glutathionylation sites, and analysis of glycoforms of glycoproteins. She is also interested in the investigation of the surface topology and the analysis of conformational changes in proteins by combining limited proteolysis and selective chemical modifications experiments with advanced mass spectrometric methodologies. This procedure was employed for the analysis of protein–protein and protein–DNA complexes and then extended to the investigation of molecular mechanisms involved in fibril formation from amyloidogenic proteins. More recently, Prof. Monti’s scientific activity has focused on proteomics studies on the elucidation of the molecular mechanisms of complex biological processes such as signal transduction pathways and regulation of gene transcription both in physiological and pathological conditions. The biological functions exerted in vivo by a specific protein are investigated by the identification of its protein partners (interactome investigation), while the alteration in proteome profiles of samples differently treated is unraveled by differential proteomics approaches

Dr. Flora Cozzolino

CEINGE-Biotecnologie Avanzate, University of Naples Federico II, Via Gaetano Salvatore, 486 – 80145 Napoli, Italy
Interests: The scientific activity of Prof. Maria Monti has always addressed the structural characterization of proteins and glycoproteins using classical protein chemistry procedures in combination with advanced biomolecular mass spectrometric methodologies, especially studies focused on protein folding, characterization of post-translational modifications, including assignment of S-S bridges, identification of glycosylation and S-glutathionylation sites, and analysis of glycoforms of glycoproteins. She is also interested in the investigation of the surface topology and the analysis of conformational changes in proteins by combining limited proteolysis and selective chemical modifications experiments with advanced mass spectrometric methodologies. This procedure was employed for the analysis of protein–protein and protein–DNA complexes and then extended to the investigation of molecular mechanisms involved in fibril formation from amyloidogenic proteins. More recently, Prof. Monti’s scientific activity has focused on proteomics studies on the elucidation of the molecular mechanisms of complex biological processes such as signal transduction pathways and regulation of gene transcription both in physiological and pathological conditions. The biological functions exerted in vivo by a specific protein are investigated by the identification of its protein partners (interactome investigation), while the alteration in proteome profiles of samples differently treated is unraveled by differential proteomics approaches

Dr. Ilaria Iacobucci

CEINGE-Biotecnologie Avanzate, University of Naples Federico II, Via Gaetano Salvatore, 486 – 80145 Napoli, Italy
Interests: Ms. Iacobucci’s research mainly focuses on the investigation of protein networks and differential protein expression to clarify cellular pathways in physiological as well as pathological conditions by functional and differential proteomics approaches applied to different scientific problems. She also studies in vitro protein–protein and protein–ligand complexes combining biochemical procedures and mass spectrometry techniques. She is also focused on systems biology approaches using bioinformatic tools for the analysis of proteomic data