{"id":543,"date":"2021-03-10T12:21:56","date_gmt":"2021-03-10T11:21:56","guid":{"rendered":"http:\/\/www.itpa.it\/?p=543"},"modified":"2021-03-10T12:21:56","modified_gmt":"2021-03-10T11:21:56","slug":"special-issue-mitochondrial-proteomics-in-neuroscience-and-neurodegenerative-disease","status":"publish","type":"post","link":"https:\/\/www.itpa.it\/index.php\/special-issues\/special-issue-mitochondrial-proteomics-in-neuroscience-and-neurodegenerative-disease\/","title":{"rendered":"Special Issue “Mitochondrial Proteomics in Neuroscience and Neurodegenerative Disease”"},"content":{"rendered":"

A special issue of\u00a0International Journal of Molecular Sciences<\/i><\/a>\u00a0(ISSN 1422-0067). This special issue belongs to the section “Molecular Immunology<\/a>“.<\/p>\n

webpage\u00a0https:\/\/www.mdpi.com\/journal\/ijms\/special_issues\/MP_ND<\/a><\/p>\n

Deadline for manuscript submissions:\u00a031 August 2021<\/b><\/span>.<\/p>\n

Special Issue Editors<\/strong><\/p>\n

Dr. Viviana Greco\u00a0<\/strong><\/p>\n

Guest Editor
\nDepartment of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Universit\u00e0 Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy
\nInterests: hydrogen sulfide; mass spectrometry; mitochondrial biochemistry; mitochondrial proteomics; neurodegenerative diseases; oxidative stress; PTMs; redox proteomics<\/p>\n

Dr. Luisa Pieroni <\/strong><\/p>\n

Guest Editor
\nUnit\u00e0 di Proteomica e Metabolomica, Fondazione S. Lucia IRCCS, 00179 Roma, Italy
\nInterests: proteomics; mitochondrial proteomics; mitochondria biology; neurodegenerative disease; metabolism; oxidative phosphorylation; biomarkers<\/p>\n

Special Issue Information<\/strong>
\nMitochondria play a key role as energy mediators and in the biosynthesis of eukaryotic cells, so they are recognized as the cell\u2019s powerhouse. In addition to this function in cellular bioenergetics, mitochondria are involved in several other pathways such as the regulation of cell death processes, the modulation of ionic homeostasis, and the oxidation of carbohydrates and fatty acids. Therefore, it is not surprising that mitochondrial dysfunctions or alterations can have a serious impact both in defects of energy metabolism and in the multifactorial diseases in which they are directly involved.<\/p>\n

The involvement of mitochondria in the pathogenic mechanisms of neurodegenerative disorders (for example amyotrophic lateral sclerosis, Alzheimer\u2019s and Parkinson\u2019s diseases, and Down\u2019s syndrome) has been well established. In recent years, many efforts have been made to understand these mechanisms, especially through the advances of the omics sciences.<\/p>\n

From this perspective, mitochondria have become a \u201chotspot\u201d for subcellular proteomics, with the aim of identifying clinical targets as candidate biomarkers in neurodegenerative diseases.<\/p>\n

The purpose of this Special Issue is to gather the latest information and highlight the state of the art in the progress of mitochondrial proteomics in order to highlight yet-unknown aspects, or to clarify the complex mechanisms, linked to mitochondrial dysfunction in neurodegenerative diseases.<\/p>\n

Reviews, commentaries, and original research based on proteomics and mass spectrometry are welcome (for example, discovery, quantitative aspects, PTMs, and redox proteomics), independently or in combination with other, more classic biochemical, molecular, and cellular approaches.<\/p>\n

Dr. Viviana Greco<\/strong>
\nDr. Luisa Pieroni<\/strong>
\nGuest Editors<\/strong><\/p>\n

Keywords<\/strong>
\nProteomics
\nMass Spectrometry
\nMitochondria
\nMitochondria Function
\nNeurodegeneration
\nMetabolism
\nNeuronal activity
\nNeuronal plasticity
\nMitochondrial protein function
\nMitochondrial protein annotation
\nOXPHOS
\nBiomarkers
\nAging
\nDrug Target
\nDrug Repurposing
\nKnowledge Base
\nAntibodies<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

A special issue of\u00a0International Journal of Molecular Sciences\u00a0(ISSN 1422-0067). This special issue belongs to the section “Molecular Immunology“. webpage\u00a0https:\/\/www.mdpi.com\/journal\/ijms\/special_issues\/MP_ND Deadline for manuscript submissions:\u00a031 August 2021. Special Issue Editors Dr. Viviana Greco\u00a0 Guest Editor Department...<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-543","post","type-post","status-publish","format-standard","hentry","category-special-issues"],"_links":{"self":[{"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/posts\/543","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/comments?post=543"}],"version-history":[{"count":1,"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/posts\/543\/revisions"}],"predecessor-version":[{"id":544,"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/posts\/543\/revisions\/544"}],"wp:attachment":[{"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/media?parent=543"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/categories?post=543"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.itpa.it\/index.php\/wp-json\/wp\/v2\/tags?post=543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}