Special Issue “Mitochondrial Proteomics in Neuroscience and Neurodegenerative Disease”

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section “Molecular Immunology“.

webpage https://www.mdpi.com/journal/ijms/special_issues/MP_ND

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Dr. Viviana Greco 

Guest Editor
Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy
Interests: hydrogen sulfide; mass spectrometry; mitochondrial biochemistry; mitochondrial proteomics; neurodegenerative diseases; oxidative stress; PTMs; redox proteomics

Dr. Luisa Pieroni

Guest Editor
Unità di Proteomica e Metabolomica, Fondazione S. Lucia IRCCS, 00179 Roma, Italy
Interests: proteomics; mitochondrial proteomics; mitochondria biology; neurodegenerative disease; metabolism; oxidative phosphorylation; biomarkers

Special Issue Information
Mitochondria play a key role as energy mediators and in the biosynthesis of eukaryotic cells, so they are recognized as the cell’s powerhouse. In addition to this function in cellular bioenergetics, mitochondria are involved in several other pathways such as the regulation of cell death processes, the modulation of ionic homeostasis, and the oxidation of carbohydrates and fatty acids. Therefore, it is not surprising that mitochondrial dysfunctions or alterations can have a serious impact both in defects of energy metabolism and in the multifactorial diseases in which they are directly involved.

The involvement of mitochondria in the pathogenic mechanisms of neurodegenerative disorders (for example amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s diseases, and Down’s syndrome) has been well established. In recent years, many efforts have been made to understand these mechanisms, especially through the advances of the omics sciences.

From this perspective, mitochondria have become a “hotspot” for subcellular proteomics, with the aim of identifying clinical targets as candidate biomarkers in neurodegenerative diseases.

The purpose of this Special Issue is to gather the latest information and highlight the state of the art in the progress of mitochondrial proteomics in order to highlight yet-unknown aspects, or to clarify the complex mechanisms, linked to mitochondrial dysfunction in neurodegenerative diseases.

Reviews, commentaries, and original research based on proteomics and mass spectrometry are welcome (for example, discovery, quantitative aspects, PTMs, and redox proteomics), independently or in combination with other, more classic biochemical, molecular, and cellular approaches.

Dr. Viviana Greco
Dr. Luisa Pieroni
Guest Editors

Keywords
Proteomics
Mass Spectrometry
Mitochondria
Mitochondria Function
Neurodegeneration
Metabolism
Neuronal activity
Neuronal plasticity
Mitochondrial protein function
Mitochondrial protein annotation
OXPHOS
Biomarkers
Aging
Drug Target
Drug Repurposing
Knowledge Base
Antibodies